Dr. Nidhi Gour

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Dr. Nidhi Gour
Chemical Biologist (PhD IIT Kanpur)


Assistant Professor, Department of Chemistry
Indian Institute of Advanced Research
University of IAR
Puri Foundation for Education in India
Koba, Gandhinagar, Gujarat, India
Ph: +91-79-30514142
Fax: +91-79-30514110
Email :  nidhigour@iiar.res.in; gournidhi@gmail.com


Academics:

  • M. Sc. (Life Sciences) Department of Life Sciences, Devi Ahilya Vishwavidyalaya (DAVV), Indore (2004)
  • PhD, Department of Chemistry, Indian Institute of Technology-Kanpur (IITK) (2004-2010)
  • Visiting Fellow, Department of Chemistry, Tata Instititute of Fundamental Research (TIFR), Mumbai (2010)
  • Post doctoral Fellow, Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York, USA (2010- 2011)
  • Post doctoral Fellow, Department of Inorganic and Analytical Chemistry, University of Geneva, Switzerland (2011-2013)
  • Post doctoral Fellow, Department of Chemistry, University of Florence, Italy (2013-2014)
  • Assistant Professor; University and Institute of Advanced Research, Koba, Gandhinagar - 382007.Gujarat, India.
  • Key Awards/Honors:

    1. Received Extramural Research Grant from DST SERB in 2016 as Principle Investigator .
    Project title: ‘A novel nanoparticle based bioassay for sensitive detection of cancer specific proteases.’

    2. PhD Thesis was selected for 2nd Prize of “2010 Eli Lilly and Company Asia Outstanding Thesis Awards”.  

    3. Received CSGI Postdoctoral Research Grant for conducting research in Nano structured self-assemblies in University of Florence, Italy

    4. Received Postdoctoral Research Fellowship from Swiss National Science Foundation for conducting research on polymer and peptide self-assemblies in University of Geneva Switzerland.

Research Interests:

My research is based on synthesis and characterization of compounds/nanoparticles with potential applications in biology.  In this context, I am currently probing the role of fullerenes, helicenes, Binols and heterocycles for their anti-amyloidogenic action. We are also currently working on developing a simple and efficient nanoparticle based assay which could detect potential anti-amyloidogenic compounds in a cost effective manner. We are also interested to develop a peptide based nanoparticle probe which could sense cancer specific proteases at very minute concentrations. Our research interest also involves designing novel nanomaterials by utilizing biomolecular self-assembly. We aim to design biocompatible self-assembled structures which can potentially be used in drug delivery and biosensing.
Thus, at present we are interested in collaborating with research teams working in the area of 

Amyloid-associated diseases
Biomolecular self-assembly
Nanoparticles for biosensing and therapy

We are also looking for motivated students at both undergraduate and postgraduate level to join our team and explore this exciting area of research. Prospective PhD and Postdoctoral fellows are also invited to join the team but the fellowship will depend on the availability of research grants.
Interested candidates may write directly to Dr. Nidhi Gour at gournidhi@gmail.com or nidhigour@iiar.res.in

Research Publications:

1. Kedracki, D.; Fillipov, S. K.; Gour,  N.; Vebert-Nardin C; Schlaad, H. “Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism.” Macromolecular Rapid Communication 2015, 36, 768-773. (impact factor 4.6)

2. Jancy, B.; Gour, N.; Bolisetty, S.; Mezzenga, R.; Vebert-Nardin C. "Controlled aggregation of peptide-DNA hybrids into amyloid-like fibrils" Europeon Polymer Journal  2015, 65, 269-275. (impact factor 3.24)

3. Gour, N.; Jancy, B.; Castillo, A.; Chiami, M.; Verma S.; Vebert-Nardin C."‘Label-free, Optical Sensing of the Supramolecular Assembly into Fibrils of a Ditryptophan-DNA Hybrid’ Chemical Communication 2014, 50, 6863-6865. (impact factor 6.718)

4. Gour, N.; Ngo, K.; Vebert-Nardin, C. “Anti-infectious Surfaces Achieved by Polymer Modification.” Macromolecular Materials and Engineering 2014, 299, 648-668. (impact factor 2.339)

5. Burman, A. K.; Gour, N.; Verma, S. "Morphological transition triggered by mannose conjugation to a cyclic hexapeptide“ ARKIVOC 2013 (ii) 82-99 in honour of Prof R R Schmidt (Univ of Konstanz). (impact factor 1.25)

6. Gour, N.; Kedracki, D.; Safir, I.; Ngo, K. Vebert-Nardin, C. “Self-Assembling DNA-Peptide Hybrids: Morphological Consequences of Oligonucleotide Grafting to Pathogenic Amyloid Fibrils Forming Peptides.” Chemical communications 2012, 48, 5440-5442. (impact factor 6.718)

7. Gour, N.; Burman, A. K.; Verma, S. “Controlling morphology of peptide based soft structures by covalent modifications.”  J. Pept. Sci. 2012, 18, 405-412. (impact factor 2.071)

8. Gour, N.; Mondal, S.; Verma, S.  “Synthesis and self-assembly of a neoglycopeptide: Morphological studies and ultrasound mediated DNA encapsulation.”   J. Pept. Sci. 2011, 17, 148-153. (impact factor 2.071)

9. Gour, N.; Verma, S. “Bending of peptide nanotubes by focused electron and ion beams.” Soft Matter, 2009, 5, 1789 –1791. (impact factor 4.151)

10. Gour, N.; Purohit, C. S.; Verma, S.; Puri, R.; Ganesh, S. “Mannosylated self-assembled structures for molecular confinement and gene delivery applications.” Biochem. Biophys. Res. Commun. 2009, 378, 503-506. ( 5-year impact factor 2.5)

11. Gour, N.; Verma, S. “Synthesis and AFM studies of lectin carbohydrate self-Assemblies.” Tetrahedron, 2008, 64, 7331-7337. ( 5-year impact factor 2.899)

Book Chapters:

1. Kedracki, D.; Safir, I.; Gour, N.; Ngo, K.; Vebert-Nardin, C. “DNA-Polymer Conjugates:     From Synthesis, Through Complex Formation and Self-assembly to Applications” in Advances in Polymer Science 2013, 253, 115-150 in H. Schlaad “Biosynthetic polymer conjugates” (5-year impact factor 6.192)

2. Vijaya Krishna, K.; Gour, N.; Verma, S."Peptide-based soft spherical structures" in John Wiley & Sons, 2013, in C. Alemán, A. Bianco, M. Venazi "Peptide .Materials: From Nanostructures to Applications" DOI: 10.1002/9781118592403.ch7

Reviewer for journals:

  • Serving as a reviewer for Analytical and Bioanalytical Chemistry Journal (Impact Factor; 3.578) from Springer publishers.