Dr. Satyendra Mishra


 



Dr. Satyendra Mishra
Department of Medicinal Chemistry
Indian Institute of Advanced Research
University of IAR
Puri Foundation for Education in India
Koba, Gandhinagar, Gujarat, India
Ph: +91-79-30514130
Fax: +91-79-30514110
Email : satyendramishra@iar.ac.in; satyendramishra1@gmail.com


Academics:

2011- 2014    Staff Scientist –III (Project), National Institute of Immunology, New Delhi
2009- 2011    Postdoctoral Research Associate, Medicinal Chemistry, University of Minnesota, USA,   
2008- 2009    Postdoctoral Research Associate, Chemistry Department, University of Connecticut, USA,
2005- 2008    DBT Postdoctoral Fellow, Molecular Biophysics Unit, Indian Institute of Science, India,
2000-2004     D. Phil. Department of Chemistry, University of Allahabad, India

 

Research Interests:

  • Organic synthesis, Bio-organic /Medicinal Chemistry
  • Synthesis of small bioactive molecule and its analogs for therapeutic development i.e. cancer and neurodegenerative disorders
  • Peptidomimetics: Applications to the design of therapeutic agents
 

Research Publications:

1. Nuzhat Ahsan, Satyendra Mishra; Manish, Jain, Avadhesha, Surolia, Sarika Gupta; Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein Scientific Report 2015, 9862(DOI: 10.1038/srep09862) IF 5.08

2. Niki S. Jha*, Satyendra Mishra*, Shailendra K. Jha and Avadhesha Surolia; Antioxidant activity and electrochemistry of phenolic O-H and methylene hydrogen attached to β-diketone of curcumin and modified analogs. Electrochimica Acta, 2015, 151, 574-583. *equal contribution. IF 4.086

3. Divya Tomar, Tarique Khan, Rajiv Ranjan Singh Satyendra Mishra, Sarika Gupta, Avadhesha Surolia, Dinakar M. Salunke, Crystallographic Study of Novel Transthyretin Ligands Exhibiting Negative-Cooperativity between Two Thyroxine Binding Sites, PlosOne, September 2012, Volume 7, Issue 9, e43522. IF 4.092

4. Swapna Bhagwanth, Satyendra Mishra, Ritesh Daya, Jordan Mah, Ram K. Mishra, and Rodney L. Johnson , Transformation of Pro-Leu-Gly-NH(2) Peptidomimetic Positive Allosteric Modulators of the Dopamine D(2) Receptor into Negative Modulators. ACS Chem Neurosci. 2012, 18; 3(4):274-84. IF 4.21

5. Satyendra Mishra, Krishanpal Karmodiya, Namita Surolia; Avadhesha Surolia. Synthesis and exploration of novel curcumin analogues as antimalarial agents.  Bioorg. Med. Chem., 2008, 16(6), 2894-2902. IF 2.951

6. Satyendra Mishra, Krishanpal Karmodiya, Prasanna Parasuraman, Avadhesha Surolia Namita Surolia.  Design, synthesis and application of novel triclosan prodrugs as potential antimalarial and antibacterial Agents.  Bioorg. Med. Chem., 2008, 16(10), 5536-5546. IF 2.951

7. T. N. C Ramya, Satyendra Mishra, Krishanpal Karmodiya, Namita Surolia; Avadhesha Surolia. Inhibitors of non-housekeeping functions of the apicoplast defy delayed death in Plasmodium falciparum. Antimicrob. Agents Chemother.  2007, 51(1), 307-316. IF 4.565,

8. Roli Mishra, Satyendra Mishra, Krishna Misra. Synthesis and application of fluorous-tagged oligonucleotides.  Chem. Lett., 2006, 35(10), 1184-1185. IF 2.07

9. Satyendra Mishra, Snehlata Tripathi, Roli Mishra and Krishna Misra. Design, synthesis and characterisation of a novel anticancer prodrug having antiproliferative activity against prostrate tumour, Ind. J. Chem., 2005, 44B, (10), 2582-25-88 IF 0.787,

10. Satyendra Mishra, Neha Kapoor, A. Mubarak Ali, B. V. V. Pardhasaradhi, A. Leela Kumari, Ashok Khar, Krishna Misra Differential apoptotic and redox regulatory activities of curcumin and its derivatives. Free Radic. Biol. Med. 2005, 38 1353– 1360. IF 5.71,

11. Vibha Shukla, Satyendra Mishra, Geeta Watal and Krishna Misra; Design, development and Synthesis of a novel labeled PNA monomer incorporated in DNA- hexamer to act as hybridization probe by FRET. Ind. J. Chem., 2005, 44B (1), 121-129. IF 0.787

12. Satyendra Mishra, Upama Narain, Roli Mishra and Krishna Misra. Design, development and synthesis of mixed bioconjugates of piperic acid-glycine, curcumin-glycine/alanine and curcumin–glycine-piperic acid and their antibacterial and antifungal properties. Bioorg. Med. Chem., 2005, 13, 1477–1486. IF 2.951

13. Arvind Misra, Satyendra Mishra and Krishna Mishra. Synthesis and Fluorescence Studies of Multiple labeled Oligonucleotides containing Dansyl Fluorophore covalently attached at 2'-terminius of Cytidine via Carbamate linkage. Bioconjug. Chem., 2004, 15, 638-646. IF 4.821

14. Niki. Jha, Satyendra Mishra, and Avadhesha Surolia, Targeting Human Telomeric G- Quadruplexes DNA with Curcumin and Its Structural Analogues under Molecular Crowding Condition: Biophysical and
Spectroscopic Studies.
2015 (Submitted).

 

Symposia / Conferences/ Work shop attended:

1. Ahsan N.; Mishra S.; Gupta S.; Surolia  A. Exploration of curcumin analogues as inhibitors of alpha Synuclein aggregation for treatment of  Perkinson Disease (PD). Movement Disorders 2013; 28 Suppl 1 : 608 for MDS 17th International Congress of Parkinson's Disease and Movement Disorders and XX World Congress on Parkinson’s Disease and related disorders conference proceedings‟. Geneva, Switzerland, 8-11 December 2013

2. Satyendra Mishra,  Swapna Bhagwanth,  Ritesh P. Daya,  Jordan K. Mah, Ram K. Mishra, Rodney L. Johnson.  Design of negative allosteric modulators of the dopamine D2 receptor. 242nd ACS National Meeting, Denver, CO, August 28 - September 1 2011.

3. R. Daya, S. Mishra, S. Bhagwanth, J. K. Mah, R. L. Johnson, R. K. Mishra. Novel analogues of the tripeptide, L-Prolyl-L-Leucyl Glycinamide (PLG), modulate agonist binding to dopamine D2 receptors. Neuroscience 2011, SfN's 41st annual meeting, Nov. 12-16, Washington, DC. Program#/Poster#: 618.20/XX82.

4. 32nd National Medicinal Chemistry at University of Minnesota, Twin Cities Campus in Minneapolis, June 6-9, 2010.

5. 48th Annual MIKI Meeting Program, University of Illinois at Chicago, April 9-11, 2010.

6. IUBMB workshop on “Molecular Characterization of Glycoproteins and Glycolipids and their Interactions with Lectins and Receptors” at Bangalore, India (20-28 February  2006).

7. IUBMB Symposium on “Glycans on Proteins and Lipids: Implications in Cellular Functions and Evolution” held at Bangalore, India (20-28 February 2006).

8. Arvind Misra, Satyendra Mishra and Krishna Misra, Multiple labeling of various oilgonucleotides with dansyl labeled cytidine and their fluorescence studies on hybridizations with complementary sequences, International Conference in IUPAC, New Delhi, 2004, January 26-29.

9. Satyendra Mishra, Roli Mishra, Neha Kapoor and Krishna Misra, Apoptosis and antioxidant activity of curcumin Derivatives; role of phenolic hydroxyls and active methylene hydrogen, Sixth National Symposium in Chemistry, IIT Kanpur February 6-8, 2004.

10. Roli Mishra, Satyendra Mishra and Krishna Misra, An Improved procedure for synthesis of oligonucleotides, CONIAPS -VI, Gorkhapur February 6-8 2004.

11. Satyendra Mishra, Roli Mishra, Neha Kapoor and Krishna Misra, Apoptosis and antioxidant activity of curcumin Derivatives; role of phenolic hydroxyls and active methylene hydrogen, Drug Discovery Today, USA, 2004.

12. Satyendra Mishra, Upma Narain, Roli Mishra Shiv Kumar Dubey    and Krishna Misra Design and development of curcumin-piperic acid bioconjugates and their antibacterial and antifungal activity. Biotech Research Society of India, Jalgaon,   India, Nov 25-27, 2004.

13. Satyendra Mishra, Roli Mishra, Neha Kapoor and Krishna Misra, Apoptosis and antioxidant activity of curcumin Derivatives; role of phenolic hydroxyls and active methylene hydrogen, Third Indian Science Congress February 19-21, 2004.

14. Satyendra Mishra, Snehlata Tripathi and Krishna Misra; Synthesis and design of novel anticancer prodrug to target telomerase sequence for Cancer therapeutic. 2003, Proceedings of the 90’s Session of the Indian Science Congress.

15. Satyendra Mishra, Upama Narain and Krishna Misra; Proceedings of the National Scientific Symposium on Bio-active Molecules. Trivendrum, 23rd Oct to 25th Oct 2002.

 

 

Honours/Awards:

  • Department of Biotechnology, Postdoctoral fellowship from 2005-2008
  • Best Poster presentation award in Symposium on Bio-active Molecules at Regional Research Laboratory, Trivandrum, INDIA 23rd Oct - 25th Oct 2002.
  • Life Member of Chemical Research Society of India
  • Member of American Chemical Society