Publications by IIAR



75. V Singh, I Mani (2017) A potential screening of peptide deformylase inhibitors towards the control of Aeromonas hydrophila, Current Synthetic and Systems Biology 5 (1), 131. 

74. Palak Patel, Krupali Parmar, Vivek K. Vyas, Dhaval Patel, Mili Das, Combined in-silico approaches for the identification of novel inhibitors of human islet amyloid polypeptide (hIAPP) fibrillation, Journal of Molecular Graphics and Modelling, Volume 77, 2017, Pages 295-310.

73. Miral Lunagariya, , Khyati Thakor; Reena R Verma, Bhargav Waghela, Chandramani Pathak, Mohan Patel (2017) Synthesis, characterization and biological application of 5-quinoline 1,3,5-trisubstituted pyrazole based platinum(II) complexes.  2017 Dec. Medicinal Chemistry Communication DOI 10.1039/C7MD00472A

72. Patel B, Patel D, Parmar K, Chauhan R, Singh DD, Pappachan A., L. donovani XPRT: Molecular characterization and evaluation of inhibitors. Biochim Biophys Acta. 2017 Dec 9;1866(3):426-441. doi: 10.1016/j.bbapap.2017.12.002.

71. Patel D, Gaikwad S, Challagundla N, Nivsarkar M, Agrawal-Rajput R. Spleen tyrosine kinase inhibition ameliorates airway inflammation through modulation of NLRP3 inflammosome and Th17/Treg axis. Int Immunopharmacol. 2018 Jan; 54:375-384. doi: 10.1016/j.intimp.2017. 11. 026.

70. Singh V. 2017. Systems and synthetic biology. Frontiers in Bioengineering and Biotechnology 5:50.

69. Singh V, Gohil N, and Remirez-García R. 2017. New insight into the control of peptic ulcer by targeting the histamine H2 receptor. Journal of Cellular Biochemistry  DOI:10.1002/jcb.26361.

68. Kumar M, Ranjan K, Singh V, Pathak C, Pappachan A, Singh DD. (2017). Hydrophilic Acylated Surface Protein A (HASPA) of Leishmania donovani: Expression, Purification and Biophysico-Chemical Characterization. Protein J. 2017 Jun 21. doi: 10.1007/s10930-017-9726-x.

67. Kumar, A. & Tiwari, A.K. (2017). Molecular Chaperone Hsp70 and Its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster Mol Neurobiol doi:10.1007/s12035-017-0650-z

66. Singh, V., Gohil, N., Ramírez-García, R., Braddick, D. and Fofié, C. K. (2017). Recent Advances of CRISPR-Cas9 Genome Editing Technologies for Biological and Biomedical Investigations. J. Cell. Biochem. doi:10.1002/jcb.26165.

65. Panchal K, Tiwari AK.(2017) Drosophila melanogaster "a potential model organism" for identification of pharmacological properties of plants/plant-derived components. Biomed Pharmacother. May;89:1331-1345.

64. Varjani SJ. (2017) Microbial degradation of petroleum hydrocarbons. Bioresour Technol. Jan;223:277-286. Review

63. Kumar A, Christian PK, Panchal K, Guruprasad BR, Tiwari AK. (2017) Supplementation of Spirulina (Arthrospira platensis) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1βΔ93 Flies, a Parkinson's Disease Model in Drosophila melanogaster. J Diet Suppl. Sep 3;14(5):573-588.

62. Ambastha V, Sopory, SK, Tiwari BS , Tripathy BC (2017). Photo-modulation of programmed cell death in rice leaves triggered by salinity. Apoptosis, ;22(1):41-56. doi: 10.1007/s10495-016-1305-7 

61. Lunagariya MV, Thakor KP, Waghela BN, Vaidya FU, Pathak C, Patel MN. (2017) Design, synthesis, MTT assay, DNA interaction studies of platinum(II) complexes. J Biomol Struct Dyn. Jan 4:1-18


60. Varjani SJ, Upasani VN. (2016) Biodegradation of petroleum hydrocarbons by oleophilic strain of Pseudomonas aeruginosa NCIM 5514. Bioresour Technol. Dec;222:195-201

59. Varjani SJ, Upasani VN. (2016) Carbon spectrum utilization by an indigenous strain of Pseudomonas aeruginosa NCIM 5514: Production, characterization and surface active properties of biosurfactant. Bioresour Technol. Dec;221:510-516.

58. Varjani SJ, Upasani VN. (2016) Core Flood study for enhanced oil recovery through ex-situ bioaugmentation with thermo- and halo-tolerant rhamnolipid produced by Pseudomonas aeruginosa NCIM 5514. Bioresour Technol. Nov;220:175-82.

57. Niki Sweta Jha, Satyendra Mishra, Ashalatha Sreshty Mamidi, Archita Mishra, Shailendra Kumar Jha and A Surolia, (2016) Targeting Human Telomeric G-Quadruplexes DNA with curcumin and its synthesized analogues under molecular crowding condition, RSC Adv., 6, 7474-7487.

56. Shalini Srivastava; Satyendra Mishra; Avadhesha Surolia; Dulal Panda (2016) C1, a highly potent novel curcumin derivative, binds to tubulin, disrupts microtubule network and induces apoptosis. Bioscience Reports Mar 15.

55. Panchal K, Patel K, Tiwari AK (2016). Dietary Supplementation of Citric acid (monohydrate) Improves Health Span in Drosophila melanogaster. Journal of Applied Biology & Biotechnology Vol. 4 (02), pp. 060-066.

54. Sonani R, Rastogi R, Singh NK, Thadani J, Patel PJ, Kumar J, Tiwari AK, Devkar RV, Madamwar D (2016). Phycoerythrin averts intracellular ROS generation and physiological functional decline in eukaryotes under oxidative stress. Protoplasma. DOI 10.1007/s00709-016-0996-5.

53. Kishu Ranjan and Chandramani Pathak (2016) Expression of FADD and cFLIPL balances mitochondrial integrity and redox signaling to substantiate apoptotic cell death. Molecular and Cellular Biochemistry.

52. Mansuri MS, Laddha NC, Dwivedi M, Patel D, Alex T, Singh M, Singh DD, Begum R. (2016) Genetic variations (Arg5Pro and Leu6Pro) modulate the structure and activity of GPX1 and genetic risk for vitiligo.  Exp Dermatol; 25(8): 654-7.

51. Sahni R,  Sahni M, (2016), Stability of a New Modified Iterative Algorithm, Proceedings of the International Multi Conference of Engineers and Computer Scientists 2016, Vol I, IMECS 2016, March 16 - 18, 2016, Hong Kong.

50. Patel D. K., Shah K. R., Pappachan A., Gupta S., Singh D. D. (2016) Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol.

49. Ranjan K, Pathak C (2016) FADD regulates NF-κB activation and promotes ubiquitination of cFLIPL to induce apoptosis. Scientific Reports. 2016 Mar 14;6:22787. doi: 10.1038/srep22787.

48. Sagar Gaikwad, Divyesh Patel and Reena Agrawal-Rajput. (2016) CD40 Negatively Regulates ATP-TLR4-Activated Inflammasome in Microglia. Cellular and Molecular Neurobiology 03/2016. doi: 10.1007/s10571-016-0358-z. Pubmed.

47. Sagar Gaikwad, Naveen CR and Reena Agrawal-Rajput. (2016) Toll-like receptor-4 antagonism mediates benefits during neuroinflammation. Neural Regeneration Research 2016 Apr;11(4):552-3. doi: 10.4103/1673-5374.180732

46. Sagar Gaikwad, Naveen CR and Reena Agrawal-Rajput. (2016) Berberine Induces Neuronal Differentiation through Inhibition of Cancer Stemness and Epithelial-Mesenchymal Transition in Neuroblastoma Cells. Phytomedicine  2016 Jun 15;23(7):736-44. doi: 10.1016/j.phymed.2016.03.013. Epub 2016 Apr 13. Pubmed

45. Vinothkumar K, Kumar GN and Bhardwaj AK. (2016) Characterization of Vibrio fluvialis qnrVC5 gene in native and heterologous hosts: Synergy of qnrVC5 with other determinants in conferring quinolone resistance. Front Microbiol. 7:146.


44. Sahni M, Sahni R (2015), Rotating Functionally Graded Disc with Variable Thickness Profile and External Pressure, Procedia Computer Science 57 ( 2015 ) 1249 – 1254.

43. Sagar Gaikwad, Divyesh Patel, Naveen C. R. and Reena Agrawal-Rajput. (2015) The critical role of JNK and p38 MAPKs for TLR4 induced microgliamediated neurotoxicity. European Journal of Experimental Biology, 5(8):34-42.

42.Gaikwad S, Agrawal-Rajput R. (2015) Lipopolysaccharide from Rhodobacter sphaeroides Attenuates Microglia-Mediated Inflammation and Phagocytosis and Directs Regulatory T Cell Response. International Journal of Inflammation; (7). doi:10.1155/2015/361326. Pubmed.

41. Ranjan K and Pathak C. (2015) Expression of cFLIPL Determines the Basal Interaction of Bcl-2 with Beclin-1 and Regulates p53 Dependent Ubiquitination of Beclin-1 During Autophagic Stress. J Cell Biochem. Dec 18. doi: 10.1002/jcb.25474. [Epub ahead of print]

40. Shah KR, Patel DK, Pappachan A, Prabha CR, Singh DD.  (2015) Characterization of a Kunitz-type serine protease inhibitor from Solanum tuberosum having lectin activity. Int J Biol Macromol. 83;259-69.

39. Singh V., Nair D., Kaushal R. S., Kumar M., Pappachan A., Singh D. D. (2015) Heterologous expression, purification and characterization of L-type lectin homologue from Leishmania donovani. Biotechnology Reports, 8: 81-87. doi:10.1016/j.btre.2015.09.004

38. Rajpara N, Kutar BMRNS, Sinha R, Nag D, Koley H, Ramamurthy T and Bhardwaj AK. (2015) Role of integrons, plasmids and SXT elements in multidrug resistance of Vibrio cholerae and Providencia vermicola obtained from a clinical isolate of diarrhea. Front Microbiol. 17;6:57.

37. Bhardwaj AK and Vinothkumar K. (2015) Evolution of MDRs. Quorum Sensing Vs Quorum Quenching: A battle with no end in sight Springer India.

36. Ashima Kushwaha Bhardwaj. Multi-drug resistance in vibrios - Never underestimate bacteria.  Advances in Biotechnology and Allied Areas.  2015. I. K. International Publishing House Pvt. Ltd., Delhi.  Editors: Neelu Nawani, Madhukar Khetmalas, Ashok Pandey, P. M Razdan and K. B Powar.  

35. Suhashini S. Dhumale, Bhargav N. Waghela and Chandramani Pathak (2015) Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB Life, In press.

34. Bhargav N. Waghela, Anupama Sharma and Chandramani Pathak (2015) Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptotic cell death in human colon carcinoma cells. Plos One DOI: 10.1371/journal.pone.0117526.

33. Debashree Sengupta, Dhiraj Naik and Atipalli R. Reddy (2015) Plant aldo-keto reductases (AKRs) as multi-tasking soldiers involved in diverse plant metabolic processes and stress defense: a structure-function update. Journal of Plant Physiology .179:40-55. 


32. Pooja Patel and Rajani Nadgauda. Development of Simple, Cost Effective Protocol for Micropropagation of Tylophora indica (Burm f.) Merill., an Important Medicinal Plant. European Journal of Medicinal Plant; 4(11): 1356-1366, 2014

31. Neeraj Jain, Ganesh B. Patil, Poonam Bhargava, Rajani S. Nadgauda (2014) In Silico Mining of EST-SSRs in Jatropha curcas L. towards Assessing Genetic Polymorphism and Marker Development for Selection of High Oil Yielding Clones. American Journal of Plant Sciences, 2014, 5, 1521-1541

30. Ashima Kushwaha Bhardwaj*, Kittappa Vinothkumar, Neha Rajpara, Priyabrata Mohanty and Braj Mohan Ram Narayan Singh Kutar Therapeutic Limitations Due to Antibiotic Drug Resistance: Road to Alternate Therapies.  Frontiers in Anti-Infective Drug Discovery (e. book), Vol. 3, 2014.  Bentham Science Publishers.  Editors: Atta-ur-Rahman and M. Iqbal Choudhary.

29. Santosh Kumar, Rajani Nadgauda (2014). Control of Morphological Aberrations in Somatic Embryogenesis of Commiphora wightii (Arnott) Bhandari (Family: Burseraceaea) Through Secondary Somatic Embryogenesis. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci., 1-10, doi:10.1007/s40011-014-0347-2.


28. Neeraj Jain, Rajani S. Nadgauda (2013). Commiphora wightii (Arnott) Bhandari-A natural source f guggulsterone: facing a high risk of extinction in its natural habitat. American Journal of Plant Sciences 4:57-68

27. Vinothkumar K, Bhardwaj AK, Ramamurthy T, Niyogi SK. 2013. Triplex PCR assay for the rapid identification of 3 major Vibrio species, Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio fluvialis. Diagn Microbiol Infect Dis. 76(4):526-8.

26. Rajpara N, Vinothkumar K, Mohanty P, Singh AK, Singh R, Sinha R, Nag D, Koley H, Bhardwaj AK. 2013. Synergistic Effect of Various Virulence Factors Leading to High toxicity of Environmental V. cholerae Non-O1/ Non-O139 Isolates Lacking ctx Gene : Comparative Study with  Clinical Strains. PLoS One. Volume 8, issue 9, e76200.

25. Pant DC, Dave M, Tiwari AK. (2013). Wheatgrass (Triticum aestivum L.) supplementation promotes longevity in Drosophila melanogaster. Annals of Plant Sciences, 49-54.

24. Kumar A, Dave M, Pant DC, Luxar R, Tiwari AK. (2013). Vinca rosea leaf extract supplementation leads to developmental delay and several phenotypic anomalies in Drosophila melanogaster. Toxicological & Environmental Chemistry, 95:635-645.

23. Ranjan K, Sharma A, Surolia A, Pathak C. Regulation of HA14-1 mediated oxidative stress, toxic response, and autophagy by curcumin to enhance apoptotic activity in human embryonic kidney cells. Biofactors 2013 Apr 5. doi: 10.1002/biof.1098.

22. Bhardwaj AK, Vinothkumar K, Rajpara N. Bacterial quorum sensing inhibitors: Attractive alternatives for control of infectious pathogens showing multiple drug resistance. Recent Pat Antiinfect Drug Discov. 2013;8:68-83.

21. Kutar BM, Rajpara N, Upadhyay H, Ramamurthy T, Bhardwaj AK. Clinical Isolates of Vibrio cholerae O1 El Tor Ogawa of 2009 from Kolkata, India: Preponderance of SXT Element and Presence of Haitian ctxB Variant. PLoS One. 2013;8(2):e56477.


20. Tomar D, Sripada L, Prajapati P, Singh R, Singh AK. Nucleo-Cytoplasmic Trafficking of TRIM8, a Novel Oncogene, Is Involved in Positive Regulation of TNF Induced NF-kappaB Pathway. PloS one 2012; 7(11): e48662.

19. Sripada L, Tomar D, Singh R. Mitochondria: One of the destinations of miRNAs. Mitochondrion 2012; 12(6):593-9.

18. Nair, D., Singh, V., Yamaguchi, Y. and Singh, D.D. (2012). Jatropha curcas hemagglutinin is similar to a 2S albumin allergen from the same source and has unique sugar affinities. Planta 236, 1499-1505

17. Sripada L, Tomar D, Prajapati P, Singh R, Singh AK (2012). Systematic Analysis of Small RNAs Associated with Human Mitochondria by Deep Sequencing: Detailed Analysis of Mitochondrial Associated miRNA. PLoS ONE 7, e44873

16. Kishu Ranjan, Avadesha Surolia and Chandramani Pathak  Apoptotic potential of Fas-associated death domain on regulation of cell death regulatory protein cFLIP and death receptor mediated apoptosis in HEK 293T cells. J Cell Commun Signal. 2012 August; 6(3): 155–168.

15. Mohanty P, Patel A, Kushwaha Bhardwaj A. Role of H- and D- MATE-Type Transporters from Multidrug Resistant Clinical Isolates of Vibrio fluvialis in Conferring Fluoroquinolone Resistance. PLoS One. 2012;7(4):e35752. Pubmed

14. Singh AK, Singh R, Tomar D, Pandya CD, Singh R. (2012). The Leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation. Int J Infect Dis. 16, e375-81 Pubmed

13. Tomar D, Singh R, Singh AK, Pandya CD, Singh R. TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells. Biochim Biophys Acta. 1823, 316-326. Pubmed

12. Bhardwaj A K, Mohanty P. (2012) Bacterial Efflux Pumps Involved in Multidrug Resistance and their Inhibitors: Rejuvinating the Antimicrobial Chemotherapy. Recent Pat Antiinfect Drug Discov. 7, 73-89 Pubmed

11. Rochika Singh, Neha Rajpara, Jyoti Tak, Arati Patel, Priyabrata Mohanty , K. Vinothkumar,Goutam Chowdhury , T. Ramamurthy, Amit Ghosh, Ashima Kushwaha Bhardwaj. (2012) Clinical isolates of Vibrio fluvialis from Kolkata, India, obtained during 2006: Plasmids, qnr and mutation in gyrase A as mechanisms of multidrug resistance.J Med Microbiol 61, 369-74. Pubmed


10. Meenakshi Gupta, Poonam Bhargava, Neeraj Jain and Rajani Nadgauda. “A metagenomic approach to study the mycorrhizal community structure colonizing Jatropha rhizhosphere”. Agricultural Research Journal. 1(1): 264 –271.

9. Divya Nair, CG Suresh, D D Singh (2011) Purification, crystallization and preliminary X-ray characterization of an haemagglutinin from the seeds of Jatropha curcas. Acta Crystallogr Sect F Struct Biol Cryst Commun. 67, 1534-36 Pubmed


8. Heikham R, Shankar R. (2010). Flanking region sequence information to refine microRNA target predictions. J Biosci. 35, 105-18.


7. Rajpara N, Patel A, Tiwari N, Bahuguna J, Antony A, Choudhury I, Ghosh A, Jain R, Ghosh A, Bhardwaj AK (2009)  Mechanism of drug resistance in a clinical isolate of Vibrio fluvialis: Involvement of multiple plasmids and integrons.  Int J Antimicrob Agents. 2009 34(3):220-5. Pubmed

6. Singh, DD (2009). Bioinformatics-Structural Biology interface. In Bioinformatics Applications in Life and Environmental Sciences(Fulekar, M.H., ed), Capital Publishing Company (jointly with Springer publishers), New Delhi, 25-33.

5. Singh, DD (2009). Large gene families and targets for drug design. Biobytes  4, 19-21.

4. Shankar R. Kataria B. Mukerji M. (2009). Finding Alu in primate genomes with AF-1. Bioinformation 3, 287-288 Pubmed

3. S Kumar, N Jain and R Nadgauda (2009). Explant dependent, high frequency, repetitive somatic embryogenesis and plant regeneration in Commiphora wightii. Journal of Tropical Medicinal Plants. 10(2): 195 – 203.

2. Neeraj Jain, Rajani Nadgauda, and Toshiro Shigaki (2009). Mining the cation (CAX) transporter diversity for nutrition-enhanced crops and phytoremediation. International  Journal of Integrative Biology 7(1): 22-25



1. Singh, V. & Singh, D.D. (2008). Leishmania major: Genome analysis for identification of putative adhesin-like and other surface proteins. Exp. Parasitol. 118, 139-145. Pubmed